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Thats where cost, safety, and formulary alignment can truly influence decision-making

there are essentially no completed Phase III human clinical trials establishing their safety or efficacy

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DPP-4 inhibitors in clinical use today exhibit little or no binding to either DPP-8 or DPP-9

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Yes, certain medications promote weight gain and can counteract GLP-1 effects, including antipsychotics (olanzapine, clozapine), mood stabilizers (valproate, lithium), some antidepressants (mirtazapine, paroxetine), corticosteroids, and diabetes medications like insulin or sulfonylureas