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IV NAC (150 mg/kg over 60 minutes, then 50 mg/kg over 4 hours, then 100 mg/kg over 16 hours) is reserved for confirmed severe hepatotoxicity per FDA acetaminophen hepatotoxicity protocols, which provide the most applicable IV dosing framework
Recent data indicates that both receptors may interact through -arrestin-dependent pathways, potentially contributing to their cardioprotective properties without involving G protein signaling [15]
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Dias V, Junn E, Mouradian MM
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Abbreviations DPA: diprotin A ESI-MS: electrospray ionisation-mass spectrometry GIP: glucose-dependent insulinotropic polypeptide GLP-1: glucagon-like peptide-1-(736)amide TFA: trifluoroacetic acid
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