At baseline, the mean AHI was 51.5 in trial 1 and 49.5 in trial 2
People with higher starting weight generally have higher baseline calorie needs, so a calorie deficit can translate into more pounds lost early on
The speed and intensity of the response depend on a fascinating interplay of genetics, protocol, and external stimuli
Amongst these manufacturers are competent players with prior experience in commercialising GLP-1s and so intense competition is anticipated in the coming years
GLP-1 receptor agonists work by: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release when blood glucose levels are elevated Slowing gastric emptying, which moderates post-meal glucose rises (this effect may attenuate over time) Reducing appetite through effects on brain centres controlling satiety Understanding this pharmacological profile is essential when considering the hypoglycaemic potential of Wegovy
The key is training smarter, not harder, within your reduced recovery capacity