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Aside from AsPC-1, LUNA-18 exhibited significant cytotoxic activity (IC50=0.17-2.9nM) against cell lines with KRAS gene mutations, such as LS180 (colorectal cancer, KRASG12D), GSU (gastric cancer, KRASG12D), NCI-H441 (non-small cell lung cancer, KRASG12V), NCI-H2122 (non-small cell lung cancer, KRASG12C), and MiaPaCa-2 (pancreatic cancer, KRASG12C)
Some feature pre-attached needles with automatic injection mechanisms, while others require manual needle attachment and depression of an injection button
doi: 10.3389/fpubh.2017.00240 320 LabordeSMosleyEBellengerCThayerJ
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The Legal Hurdles: Why Injectable Hydroxocobalamin is a POM For patients, the legal classification of hydroxocobalamin often feels illogical and deeply frustrating
The flow-through, containing the cleaved core peptide, was collected, followed by buffer exchange using 7 mL of His6-tag buffer (20 mM Tris, 300 mM NaCl, pH 7.5)
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