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Doubling doses increases side effect risk substantially

The combination of these therapies is mechanistically appealing and may offer incremental benefit in selected patients with overlapping metabolic, renal, and cardiovascular risk

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Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]

Patients who want additional recovery options may also ask their provider about regenerative medicine treatments such as PRP therapy, especially when the goal is to support natural healing in select cases