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This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (10, 19)

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Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors

Because GIP receptor activation affects fat metabolism through pathways separate from appetite control, there is a theoretical basis for better weight maintenance at lower tirzepatide doses compared to equivalent semaglutide doses

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