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doi: 10.1016/j.intimp.2020.106627 159 SinghKBHahmERKimSHSinghSV

When activated, AMPK promotes fat utilization, glucose uptake, improved energy production, and better metabolic efficiency

Maximizing synergies while avoiding conflicts

This effect is achieved by the lowering of blood pressure in cases of diabetic patients, decreasing oxidative stress on the sensitive sperm cells, and therefore minimizing damage to their DNA cargo

The intrinsic apoptotic pathway is triggered by mitochondrial membrane permeabilization and damage

Bound glutathione makes strong interactions with adjacent protomers, thereby explaining the underlying biological role of this druggable binding pocket and delineating the pharmacophore for potential antivirals