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Compounds like AOD-9604 (a modified growth hormone fragment) and 5-amino-1MQ target fat metabolism without the GI effects that GLP-1 agonists produce

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However, this increase in water weight and gastrointestinal side effects is usually only seen in people taking a loading dose of creatine, which well explain in more detail later

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8 Limitations and evidence gaps Key gaps include limited long-term randomized clinical trials, variability in intervention timing and dosing, and insufficient stratification by age, sex, chronotype, and comorbidities