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Confirm concentration when needed: a clear-looking solution does not by itself prove full dissolution or the correct concentration
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doi: 10.1371/journal.pone.0222926 54 KrasnovABreilandMSWHatlenBAfanasyevSSkugorS
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HMGB1 serves as a broad sensor of cellular stress that maintains homeostasis by balancing cell survival and death responses while functioning as a key DAMP to activate TLR4 signaling, and the HMGB1/TLR4 axis also promotes NLRP3 inflammasome-mediated pyroptosis following intracerebral hemorrhage [198, 199]
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