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Zhenqi Liu and former UVA graduate student Nathan Weeldreyer, found about 40% of the weight people lose using brand-name drugs like Wegovy or Zepbound comes from something called fat-free mass, which is everything in your body that is not fat

(please link to liver love) Lastly, I cant say this enough listen to your body and tailor your sauna sessions to align with your needs and tolerance levels

Tirzepatide ( Zepbound ): A combination GLP-1 agonist and GIP agonist, which acts similarly to liraglutide and semaglutide

[82] The trial reported cumulative occurrence of major adverse cardiovascular events, a primary end-point event of the trial, for 569 of the 8803 patients in the semaglutide group, which were 6.5% of the participants, and for 701 of the 8801 patients in the placebo group, which were 8% of the participants, showing relative 18.8% less major adverse cardiovascular events, such as death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, occurring for participants who had received semaglutide in the trial relative to those who had received placebo over the course of around 48 months, or 34.213.7 months, which was the mean (SD) total duration of the participants in either group's exposure to the placebo or semaglutide during the trial

This aspect was important considering that GLP-1 has key interactions with GLP-1R at both ends of the peptide 27,30

I.Gil-GouveiaR.et al (2023)