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Many classical ferroptosis inducers, such as erastin and RAS-selective lethal 3, can target the xCT/GPX4 axis, and these inducers can trigger ferroptosis in cancer cells, suggesting they hold promise in the treatment of cancer [40, 42]

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Highlights: 30 mL sterile vial designed for repeated use

240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

Lee et al., 2022), MK-886 (Shi et al., 2023), BWA4C (Franchi-Miller and Saffar, 1995), PD146176 (Walters et al., 2018) and others