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10.1046/j.1432-1327.1998.2510382.x Eur J Biochem
The resulting strategy families correspond to major design objectives: improving pharmacokinetics and biodistribution [33, 37, 53, 66, 67], modulating vascular access and perfusion [11, 12, 15, 68, 69], normalizing or reprogramming stromal barriers [13, 17, 30, 32, 34, 70], enabling endogenous TME-responsive release or activation [46,47,48], reshaping antitumor immunity [29, 35, 71], and integrating imaging with therapeutic intervention [72,73,74]
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However, when liver damage progresses or other factors are present, B12 levels may become abnormal
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