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Next, we tested whether lentivirus integrated proteases could trigger death in non-hematopoietic cancer lines, including Jurkat (T cell leukemia) and U2OS (osteosarcoma) cells (Extended Data Fig

10.1177/0960327116677355 63 LuC.ZhangF.XuW.WuX.LianN.JinH.et al (2015)

The temptation to escalate the dose because nothing is happening yet is exactly the mistake the timeline section is designed to head off the mechanism is cumulative, not dose-chased

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Has the finished tablet been tested for peptide stability through its full shelf life