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We previously demonstrated that melanocytes obtained from normally pigmented vitiligo skin show cellular and molecular alterations characterized by constitutive activation of antioxidant enzymes 1 and defects in mitochondrial metabolism reflected in altered expression and activity of complex I, increased generation of reactive oxygen species (ROS), low ATP production, and modified expression of some glycolytic enzymes 2

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2015 Oct;54(8):25112 Jones DP

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The peptide, humanin, was ultimately traced to a tiny snippet of mitochondrial DNApart of the ninety-eight per cent of the human genome that had long been dismissed as junk DNA. Cohens work helped reveal that, in the three-billion-letter book that is our genome, even obscure one-liners can be an important part of the story

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