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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

The only negative is when you have to climb through a ladder with the guards around it

Therefore, total serum/plasma/whole blood total Se levels are not proper biomarkers of the functional Se pool in the body (45)

however, the fact that they likely reflect different characteristics of the intestinal barrier, is of great interest and might become of more relevance in future

Presented for research literature review only Martens CR et al