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Different macronutrients stimulate GLP-1 secretion to varying degrees: Fiber and complex carbohydrates : Dietary fiber, particularly soluble fiber, enhances GLP-1 secretion by slowing nutrient absorption and allowing more prolonged contact with L-cells in the distal intestine

Helpful strategies include: eating smaller meals avoiding greasy foods increasing protein intake staying hydrated Most patients notice improvement within a few weeks

Physicians should also exercise caution when prescribing to patients with proliferative retinopathy or severe, uncontrolled diabetes, as GH can transiently affect insulin sensitivity

Switching should be clinician-led to avoid dose mismatch and unnecessary symptoms

Clinical studies show tesamorelin increases lean body mass even while reducing visceral fat

Common side effects like nausea, vomiting, and diarrhea remain, and long-term safety for brain protection needs more study