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Moreover, the amounts of lipoic acid available in dietary supplements (50-600 mg) are likely as much as 1,000 times greater than the amounts that could be obtained from the diet
& Frishman, W
Yang, T., Zelikin, A
Currently, clinical trials are investigating efficacy of CB-839 treatment in AML (NCT02071927) ( 5 Conclusions Considering our results and those of previous studies, we suggest that CLL cells can efficiently rewire their amino-acid and glucose metabolism to evade glutaminase inhibition
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This allows the nutrient to bypass the harsh environment of the digestive tract and be delivered directly to the cells
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