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Potential benefit - A patient whose biomarkers suggest rapid metabolism of GLP-1 drugs might be offered a longer-acting formulation, while someone with strong GIP responsiveness could start on a dual-agonist right away, avoiding months of trial-and-error
Older skin may show more dramatic improvement once past the adjustment phase, having more accumulated damage to clear
Start small if you are still testing the rhythm
Exposure to sugars induces rapid GLP-1 secretion from T1R3-sensitive cells, following a dose-dependent pattern where higher stimulus concentrations lead to greater secretionan effect blocked by GLP-1 receptor antagonists (61, 67)
Amylin is co-secreted with insulin at a ratio of 100:1, that is for every 100 molecules of insulin, 1 molecule of amylin is secreted
The gastrointestinal profile tends to be milder with semaglutide, though individual responses vary considerably
