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Transient drowsiness or grogginess upon waking
This effect has major implications for treating extrapyramidal symptoms and tardive dyskinesia from antipsychotic medications
Recently, nonsteroidal antiinflammatory drugs have been shown to partially impair an equilibrium between biological functioning and degradation of aldosterone due to involvement of renal UGT2B7 in both the glucuronidation of aldosterone (deactivation) and the glucuronidation of NSAIDs (Knights et al., 2009)
Most patients report that symptoms diminish significantly after the first 34 weeks as hepatic enzymes adapt to regular lipotropic dosing
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