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As plaques grow, lysosomal signals shift from neurons to DAM, with a corresponding reduction in lysosomal proteins within dystrophic neurites

Browse all Longevity & Telomeres education Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

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[Reactions of glutathione] [PMID: 3074359] Laboratory literature summary: [Reactions of glutathione]

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Of significance to diabetes is that ER stress-induced inflammation activates the kinases JNK (JUN N-terminal kinase) and IKK (inhibitor of nuclear factor-kappa B kinase subunit beta) that phosphorylate insulin receptor substrates (e.g