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the leading candidate described in the literature is beta-3 adrenergic signaling in adipose tissue, which raises intracellular cyclic AMP, activates hormone-sensitive lipase and initiates triglyceride hydrolysis

4.3 Targeting CSCs through coordinated pathway disruption SFN demonstrates remarkable efficacy against CSCs through its ability to simultaneously disrupt multiple signaling pathways that maintain stemness and self-renewal capacity

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All groups underwent a standard 7-day acclimatization period before the start of the experiment

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