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He reported a constellation of side effects that he believed were linked to the drug, including intermittent skin and soft tissue infections, dyslipidemia, elevations in glucose, and an increase in resting heart rate
Rather than increasing every four weeks with large jumps, micro-titration protocols introduce smaller increases over longer periods
It is also unusually stable in gastric acid, which is why oral dosing is even theoretically plausible
Adapted from Wadden et al
63,64 In addition, loss of Tbc1d4 in mice that phosphorylated by Akt leads to the attenuation of downstream target activation of Rab-GTPase proteins associated with GLUT4 vesicles, and completely abolishes insulin-stimulated adipocyte glucose uptake
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