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Abrupt discontinuation is generally discouraged, as gradually tapering the dose can help minimize rebound appetite and reduce blood sugar instability
This starting dose may be titrated up if needed, but its always prudent to stick with the lowest effective dose
However, many current studies examining the relationship between RA, oxidative stress, and inflammation seem to share the conclusion that getting those factors under control is critical to stopping the arterial stiffness and damage of the disease
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