Natalie Cabrera, PharmD Ozari Clinical Content Team Clinical Content Team Licensed pharmacist with over 10 years of experience in ambulatory care and GLP-1 medication counseling
Fibrosis: ECM and its regulators In order to assess Exendin-4s impact on ATs ECM composition, we analysed expression of ECM main proteins (collagens, fibronectin and elastin), enzymes involved in their cross-linking (LOX, lysosyl oxidase and LOXL2, lysyl oxidase-like 2) and degradation (MMPs, metalloproteinases) as well as regulators of ECM remodelling (TGF1, transforming growth factor beta 1 and CTGF, connective tissue growth factor)
He suggests clinicians establish a baseline testosterone level for men taking GLP-1s and discuss their potential effects on T levels
Impact for Industry Simplifies study design for suitable MR products Aligns Canada with global ICH regions Reduces regulatory gaps between IR and MR BE evaluations Ensures consistency across submissions (especially for global filings) #HealthCanada #ICHM13A #Bioequivalence #ModifiedRelease #Pharma #RegulatoryAffairs #DrugDevelopment #ClinicalResearch #PKStudies #PharmaceuticalIndustry To view or add a comment, sign in Africas Insulin Revolution: Nigeria Joins Egypt & South Africa #Nigeria has signed a landmark deal with Shanghai Haiqiu Industry Co., Ltd
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[8] Even better, GLP-1s demonstrate a self-terminating capacity to reduce blood sugar