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were included (3 clinical trials sponsored by #FFCD, 3 cohorts) 48% metastatic, 45% doublet chemo Key findings : Factors predicting severe toxicities after 3 months of chemo : female sex, cognitive impairment in men, low albumin level, doublet chemo, impaired kidney function Factors predicting mortality at 36 months : altered IADL, anemia, increased neutrophil count, metastatic stage, and single agent chemo These results will allow treatment individualization in elderly CRC patients Patients predicted to be at risk of severe toxicities could be offered more intensive monitoring This work was supervised by Pr Thomas Aparicio & Pr Florence Canoui-Poitrine, and funded by #INCa To view or add a comment, sign in AccendoWave - A Pain #Data Company Eli Lilly is calling on European countries to make urgent improvements to their #Alzheimers disease diagnostic testing practices just weeks after nabbing a new approval on the continent for its Alzheimer's therapy Kisunla
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Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction
To prevent Wegovy from becoming too cold, never put it in the freezer
Rosenstock J, Rood J, Cobitz A, Huang C, Garber A
Owing to the wide distribution of GLP-1 receptors, the anti-inflammatory effects of GLP-1RA binding to receptors throughout the body have gradually been confirmed
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