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Some common side effects that semaglutide can have on your digestive system include: Nausea Vomiting Diarrhea Constipation Stomach upset Very little appetite Some antibiotics also cause side effects, like nausea, diarrhea, or an upset stomach, so if you are using two medications that are both causing side effects, you might feel worse than you would if just using one of them alone

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That is the test-before-you-invest posture, turning a guess into an informed conversation with your provider