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From a pharmacokinetic perspective, a half-life of approximately six days means that: Steady-state plasma concentrations are typically reached after approximately four to five half-lives that is, around four to five weeks of once-weekly dosing [1] The drug accumulates gradually in the body during the initial weeks of treatment After discontinuation, meaningful plasma levels may persist for several weeks It is worth noting that pharmacokinetic parameters may vary between individuals due to interindividual differences in body composition, metabolic rate, and other physiological factors

Research from the STEP 9 study, reported at the World Congress on Osteoarthritis, discovered additional benefits of semaglutide