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GLP-1-induced weight loss significantly reduces systolic and diastolic blood pressure, attributed to decreased sympathetic nervous system activity and improved endothelial function

Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions

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Gastrointestinal effects of GLP-1 receptor agonists: From basic science to clinical relevance