Vitamin B12 comes in several forms: Cyanocobalamin Adenosylcobalamin Methylcobalamin The natural forms of B12, that are identical to the forms found in our bodies and food, are adenosylcobalamin and methylcobalamin, and these are the active forms
A comparative study conducted between GLP-1RA + Metformin in contrast to cyproterone acetate/ethinylestradiol + Metformin in overweight PCOS women, conducted over a period of 12 weeks, implied that GLP-1 RA+Metformin was superior in reducing the waist circumferences as well as preserving blood sugar levels by improved HbA1c levels and regulating menstrual cycle
In clinical literature, the underlying phenomenon relates to how appetite-regulating hormones - particularly GLP-1, ghrelin, and leptin - interact with reward and satiety pathways in the brain
higher doses amplify the effect further
Most adverse effects are gastrointestinal and typically diminish over time as your body adjusts to the medication
doi: 10.1038/s41443-024-00895-6
