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Do not use Wegovy if: You or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Key points In the kidney, pathways of selective autophagy form an integrated decision network that links sensing of cell stress and nutrients to lysosomal capacity and organelle-specific execution

Endoplasmic reticulum stress contributes to cisplatin-induced chronic kidney disease via the PERK-PKC pathway

In addition, as with any emerging pharmacology, careful and continued analysis for potential adverse effects is required, especially as these therapies advance for treatments in genetically diverse patient populations

LaddhaNCDwivediMMansuriMSGaniARAnsarullahMRamachandranAVet al

Alternative Therapies: Transitioning to other weight management medications or strategies if GLP-1s are no longer suitable