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The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus
Recently, these drugs and their weight loss drug counterparts (Wegovy, Zepbound et al.) are extremely popular as an appetite suppressant and medication weight loss drug
These findings align with results from the SURMOUNT-5 trial and an earlier real-world study from Truveta Research, with similar patterns observed across different study designs and patient populations
This change in food intake is largely mediated by estradiol, which acts directly upon anorexigenic and orexigenic neurons, largely in the hypothalamus
Final thoughts
Retatrutide affects GLP-1, GIP, and glucagon, making it the most advanced option in this family of treatments
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