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Mechanism of Action Acetyl Group Protection : The acetyl modification acts as a molecular shield that helps protect glutathione from degrading enzymes in your digestive tract, blood plasma, and extracellular spaces
The increase of total antioxidant status, measured as Trolox equivalent antioxidant capacity, after Pycnogenol intake was highly significant compared to baseline and placebo
S., Romanyuk, A
Nature 546 (7657), 312315
It gives minimal effect on cortisol and prolactin levels
The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods
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