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Key topics covered: Mechanisms of T-cell engager activation and immune synapse formation Advances in bispecific and multispecific TCE formats Applications in cancer and emerging potential in autoimmune diseases Major challenges - on-target off-tumor toxicity, cytokine release syndrome, antigen escape, and T-cell exhaustion Strategies to improve specificity, safety, and therapeutic durability This review highlights how next-generation engineering and combination strategies may unlock the full potential of TCEs across multiple disease areas

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