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The HealthRX.com clinical team uses a four-criteria framework to determine which patients are most likely to benefit from pramlintide: (1) A1C driven primarily by postprandial excursions rather than fasting hyperglycemia, (2) body weight above goal with patient preference to avoid weight-gaining agents, (3) gastroparesis absent on clinical screening, and (4) willingness to use a separate injection device and reduce mealtime insulin proactively

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