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Synthesis of ROS-sensitive polymers (P3) To a solution of ROS sensitive compound (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 ml), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.31 g, 1.41 mmol) was quickly added into the solution

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1 ROS-mediated damage has been cited as a probable contributing cause for many common neurodegenerative diseases, suggesting that the natural antioxidant defence mechanisms are overwhelmed in these cases

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These results may inform further research into more individualized approaches in subjects with diabetes and metabolic syndrome, especially in those with significant overweight or obesity

In the highest-dose group, 16% of people stopped taking retatrutide because of side effects, while no one in the placebo group stopped for this reason