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Additionally, pro-inflammatory cytokines such as TNF-, IL-1, and IFN- boost ROS production via mitochondrial and nicotinamide adenine dinucleotide phosphate oxidase pathways [68, 69]

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This is a hard contraindication, not a caution

83 The folate cycle uses glycine and tetrahydrofolate (converted from folic acid) and produces intermediates (5,10-methylene-tetrahydrofolate and 5-methylene-tetrahydrofolate) to supply methyl groups for purine synthesis

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