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To assess the association of semaglutide with incident CUD, the study population included 587,849 patients with T2D who had active medical encounters for T2D during 12/20175/2021, were for the first time prescribed semaglutide (Ozempic) or non-GLP1-1RA anti-diabetes medications (new-user design) during 12/20175/2021(index event), had no diagnosis of CUD on or before the index event and had a diagnosis of at least one of obesity-associated comorbidities (T2D, hypertension, hypercholesterolemia, hyperlipidemia, heart diseases, stroke) on or before the index event

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Recent Findings GLP-1 RAs modulate insulin signaling, reduce neuroinflammation and oxidative stress, and improve mitochondrial functional mechanisms linked to neuroprotection

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It names subtherapeutic drug exposure, breakthrough hyperglycemia or weight regain, and unpredictable side-effect patterns

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We have written more about formaldehyde-releasing preservatives and the concerns around them at Dmdm Hydantoin, but do not get too scared, those are more theories than proven facts

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2026 Ozempic NAION Lawsuit Updates March 3, 2026 Update: The judge overseeing the federal GLP-1 vision loss litigation selected a group of plaintiffs attorneys to manage discovery and other coordinated pretrial matters involving claims that Ozempic, Wegovy and similar drugs caused permanent vision damage

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It then asks why well-powered trials have largely failed where smaller studies and real-world data succeeded, with attention to brain exposure, trial design, and patient selection, and outlines what the next generation of studies will need to test the hypothesis properly

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