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You can review the full findings in the STEP 1 trial extension on PubMed
For younger, healthier, lighter individuals, titration runs cautiously pushing past the efficacious dose tends to bring on undesirable side effects
Michaud, M., Chabli, A., Lavigne, G
Side effects were generally dose-dependent starting on a lower dose and gradually increasing may help reduce gastrointestinal discomfort
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
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