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The optimum time to induce ECD by starvation was 96 h since a decrease in angiogenic and migratory capabilities, as well as an increase in recognized markers of senescence, such as -galactosidase, were observed [116]

Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis (68)