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However, whether TMAO plays a role in this has not been reported thus far and merits further investigation

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Studies of another thiol-containing antioxidant N -acetylcysteine (NAC), at its intrinsic pH, showed that it destabilizes the biofilm matrix by chelating divalent cations (e.g., Ca 2+ and Mg 2+ ), inhibition of bacterial extracellular polysaccharide production, modulation of bacterial cell physiology and the impact on its metabolism ( Our investigation of H 2 O 2 production by GSH during disruption and killing of MRAB biofilms produced interesting results (Figures 5CE)

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The most frequently reported early effects include nausea, mild stomach discomfort, bloating, gas, and occasional diarrhea or constipation