tirzepatide and antidepressants Can (a dual GIP GLP-1 receptor agonist) cause mood swings in patients with type 2 diabetes, particularly those with a history of depression or anxiety? TrimRX | Tirzepatide Antidepressants —

doi: 10.1038/mp.2009.116 119 RehfeldtS

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This review aims to summarize the evidence regarding the nephroprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) and tirzepatide and the putative mechanisms underlying the favorable renal profile of tirzepatide

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation