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This also suggests that GLP-1RAs with distinct receptor internalisation versus lysosomal targeting propensities might differentially regulate the kinetics of this engagement, including, potentially, by slow GLP-1R internalising compounds enabling prolonged VAPB-GLP-1R interactions despite an initially reduced acute engagement, as seen in the present study, as these compounds also prevent the rapid lysosomal degradation of receptors triggered by fast internalising compounds with a high level of acute GLP-1R-VAPB engagement
Do dipeptidyl peptidase-4 inhibitors increase the risk of heart failure
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Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cells nucleus, determine which genes are switched on
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