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No studies were available that described VIP-mediated activation of goblet cells or glands in either humans or animal models of COPD

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FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

For over two decades, our formulations have leveraged the unique regenerative power of copper-binding tripeptides to address aging, photodamage, and compromised barrier function at the cellular level