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The related Athira compound fosgonimeton failed its Phase 2 Alzheimer's trial (LIFT-AD) in 2023 for efficacy, and Athira discontinued development

Results HNF4 and SAA enzymes are positively correlated in liver cancer It has long been noticed that SAA metabolism is one of the major dysregulated metabolic pathways in liver tumors 22,37

In REDEFINE 1 (NEJM 2025, n=3,417, 68 weeks), cagrilintide monotherapy at 2.4 mg produced 11.8% mean body-weight reduction versus 2.3% with placebo

However, we and others 15 have found that the response of different human cancer cells to this nutritional manipulation is heterogenous (Fig

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