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Nature 444, 854859
A phase 2, randomized, dose-finding study of the novel once-weekly human glp-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes
The Ozempic vs Mounjaro comparison is therefore more accurately framed as: semaglutide (at diabetes doses, off-licence for weight loss) vs tirzepatide (licensed for weight management)
Its sad (r/PCOS, 533 upvotes)
The triple-receptor mechanism stood out because it targets appetite, insulin, and energy expenditure all at the same time, not just one pathway
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