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In addition, the inflammatory factor of smoking was found to augment EAAT3 expression in both human and murine experimental models

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Studies show that depression scores correlate to higher quinolinic acid in the blood, and postmortem studies show more cells in the brain producing quinolinic acid in suicide victims.[ref] Hepatitis C patients treated with interferon-alpha have depression and higher kynurenine metabolites.[ref] Another reason tryptophan metabolism could tilt more towards kynurenine is when the body is lacking in niacin