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A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

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Moreover, the dose-dependent effect of HLA-DR2 haplotypes on MS susceptibility suggests a potential link between genetic factors and disease manifestation [153]

It is used for various reasons, although its benefits are not well defined

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