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Full therapeutic effects of semaglutide are typically seen with maintenance doses (0.5 to 2 mg of Ozempic and 14 mg of Rybelsus) after 12-20 weeks

This pattern is consistent with what we see across many GLP-1 receptor agonist side effects , where the body needs time to adjust to a medication that fundamentally alters appetite signaling, gastric emptying, and metabolic function

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