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For reflux or heartburn: Avoid trigger foods such as citrus, tomatoes, spicy foods, and caffeine Eat your last meal at least three hours before bedtime Elevate the head of your bed if nighttime symptoms occur General tolerance tips: Side effects often improve during or after dose escalation as your body adjusts to the medication

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Presented for research literature review only Gmez-Olivn LM et al

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

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