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The appetite effect is mediated through the same GHS-R1a receptor that ghrelin activates, triggering hypothalamic hunger signaling
Despite setting expectations before patients start GLP-1s, Thiara says many still believe the drugs will enable them to reach their ideal weight
Injectable hair protocol: Dose: 1-2mg daily Frequency: Daily or 5 days weekly Duration: 16-24 weeks minimum (longer than anti-aging protocols) Cycle: 8 weeks on, 4 weeks off, repeat Topical scalp protocol: Concentration: 0.5% solution Application: 1-2ml to thinning areas twice daily Duration: 6+ months for meaningful assessment Technique: Apply to clean, dry scalp
Vitamin K has also been shown to be involved in the regulation of glucose homeostasis and this has potentially significant clinical implications in the context of type 2 diabetes
Still, reviews are mixed
Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy
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